Pipeline

Chrysalis is pioneering the use of natural peptide regenerative drugs to restore vascular function and activate normal stem cell populations where they exist in the body. Our lead product Chrysalin™ (TP508) has demonstrated potential for clinical benefit in human clinical trials and in preclinical studies for multiple clinical indications. Chrysalis has utilized non-dilutive funding to build a diverse pipeline with focus on preventing acute lung failure and mitigating effects of radiation.

The TP508 Nuclear Countermeasure Program funded by NIH and BARDA is being developed under the FDA Animal Rule program with potential approval as early as 2027.

It has become clear that Acute Respiratory Distress Syndrome (ARDS) is an endothelial vascular disease with vascular damage similar to that seen after radiation exposure. Chrysalis is developing TP508 to treat ARDS induced infection, inflammation, or traumatic injury. The FDA has approved Chrysalis IND application to proceed with Phase I human clinical trials.

Secondary indications for radiation therapy and neural recovery following traumatic brain injury are still in preclinical development.